D2HGDH

Across TCGA pan-cancer cohorts, D2HGDH mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated D2HGDH data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher D2HGDH mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated D2HGDH expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, HNSC, and CCRCC are the cancer types where D2HGDH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	1.000	0.917	.044	12	view →
HNSC	OS	Median	All	0.937	0.995	.020	4	view →
CCRCC	OS	Median	All	0.985	0.901	.023	3	view →
LUAD	DFS	Median	All	1.000	0.887	.012	3	view →
GBM	OS	Median	All	0.827	0.802	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

D2HGDH–COAD (DFS)

Open the COAD breakdown →