D2HGDH

Across TCGA patient cohorts, D2HGDH RNA expression is significantly associated with the protein abundance of many other proteins, with 8,316 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible D2HGDH-associated proteins across cancer lineages are UBASH3B, DOK3, and HSPA13. Each is linked with D2HGDH in more than 3 cancer types. Because this analysis shows association rather than direction, both D2HGDH-to-partner and partner-to-D2HGDH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, D2HGDH versus UBASH3B in BRCA, with a Pearson correlation of -0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (D2HGDH→partner) and Y-score (partner→D2HGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UBASH3B →	-0.519	-0.916	<.001	<.001	3	4
CCRCC	DOK3 →	-0.352	-0.540	<.001	<.001	3	4
CCRCC	HSPA13 →	-0.356	-0.455	<.001	<.001	3	4
BRCA	VEZF1 →	+0.319	+0.731	.005	<.001	3	3
LSCC	MEPCE →	+0.243	+0.320	.002	.006	3	3
LUAD	MLKL_S106 →	-0.705	-0.521	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,316 associations by consensus.

D2HGDH vs UBASH3B — BRCA

Explore this scatter interactively →