D2HGDH

Across TCGA patient cohorts, D2HGDH protein abundance is significantly associated with the RNA expression of many other genes, with 5,349 significant associations in total. OV shows the largest number of these associations.

The most reproducible D2HGDH-associated genes across cancer lineages are FBXO36, TRIR, and HAUS1. Each is linked with D2HGDH in more than 3 cancer types. Because this analysis shows association rather than direction, both D2HGDH-to-partner and partner-to-D2HGDH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, D2HGDH versus FBXO36 in LSCC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (D2HGDH→partner) and Y-score (partner→D2HGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FBXO36 →	+0.617	+0.389	<.001	.006	3	4
BRCA	TRIR →	-0.292	-0.235	.008	.004	3	3
BRCA	HAUS1 →	-0.508	-0.229	<.001	.005	3	3
BRCA	SMIM31 →	+0.894	+0.315	.004	.003	3	3
OV	RNU6-118P →	-0.954	-0.594	.001	<.001	3	3
OV	N4BP2L2-IT2 →	-0.632	-0.532	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,349 associations by consensus.

D2HGDH vs FBXO36 — LSCC

Explore this scatter interactively →