D2HGDH

Across TCGA patient cohorts, D2HGDH mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible D2HGDH-associated genes across cancer lineages are p62 Lck ligand, EGFR_pY1068, and FOXO3a_pS318_S321. Each is linked with D2HGDH in more than 1 cancer types. Because this analysis shows association rather than direction, both D2HGDH-to-partner and partner-to-D2HGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by D2HGDH-low versus D2HGDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (D2HGDH→partner) and Y-score (partner→D2HGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.299	+2.469	.022	.010	3	2
UCEC	EGFR_pY1068 →	-0.249	-2.415	.013	.003	3	1
UCEC	FOXO3a_pS318_S321 →	-0.112	-2.212	.025	.010	3	1
UCEC	ACC1 →	+0.348	+2.335	.017	.018	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.534	+2.321	.009	.033	3	1
UCEC	JNK_pT183_Y185 →	-0.187	-1.893	.005	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

p62 Lck ligand by D2HGDH expression — UCEC

Explore this box plot interactively →