D2HGDH

Across TCGA cell cohorts, D2HGDH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,774 significant associations in total. BONE shows the largest number of these associations.

The most reproducible D2HGDH-associated GO terms across cancer lineages are Pre-mRNA catabolic process, Taurine biosynthetic process, and Alkanesulfonate biosynthetic process. Each is linked with D2HGDH in more than 17 cancer types. Because this analysis shows association rather than direction, both D2HGDH-to-partner and partner-to-D2HGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-mRNA catabolic process grouped by D2HGDH-low versus D2HGDH-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (D2HGDH→partner) and Y-score (partner→D2HGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Pre-mRNA catabolic process →	+0.210	+1.126	<.001	<.001	3	18
URINARY_TRACT	Taurine biosynthetic process →	+1.088	+1.459	.005	<.001	3	16
URINARY_TRACT	Alkanesulfonate biosynthetic process →	+1.088	+1.459	.005	<.001	3	16
BREAST	Otolith mineralization →	+0.169	+1.288	<.001	<.001	3	15
CNS	Positive regulation of sphingolipid biosynthetic process →	+0.130	+0.571	.005	<.001	3	15
CNS	Positive regulation of ceramide biosynthetic process →	+0.130	+0.571	.005	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,774 associations by consensus.

Pre-mRNA catabolic process by D2HGDH expression — BONE

Explore this box plot interactively →