CYYR1

Across TCGA patient cohorts, CYYR1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYYR1-associated genes across cancer lineages are Caspase-7-cleavedD198, Lck, and MIG-6. Each is linked with CYYR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYYR1-to-partner and partner-to-CYYR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CYYR1-low versus CYYR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYYR1→partner) and Y-score (partner→CYYR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.079	+3.019	<.001	.019	3	2
UCEC	Lck →	+0.399	+3.321	<.001	.010	3	2
SKCM	MIG-6 →	-0.129	-2.567	.033	.001	3	1
SKCM	PDCD4 →	+0.331	+2.087	.031	.005	3	1
SKCM	Rb →	-0.152	-1.874	.012	.047	3	1
SKCM	STAT5a →	+0.461	+1.754	.029	.047	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Caspase-7-cleavedD198 by CYYR1 expression — UCEC

Explore this box plot interactively →