CYYR1

Across TCGA pan-cancer cohorts, CYYR1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CYYR1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CYYR1 RNA is repressed in tumor relative to normal tissue. In most cancer types CYYR1 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and BLCA are the cancer types where CYYR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYYR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	IV	−2.546	<.001	11	view →
LUAD	Female	III,IV	−2.501	<.001	11	view →
BLCA	All	All	−1.372	<.001	11	view →
LUSC	Female	II,III,IV	−2.611	<.001	9	view →
KIRP	Male	All	−2.190	<.001	9	view →
UCEC	All	All	−3.095	<.001	8	view →
LIHC	Female	All	+0.874	<.001	8	view →
COAD	Female	All	−0.747	<.001	7	view →
BRCA	All	II,III,IV	−1.916	<.001	6	view →
KIRC	All	All	+0.515	<.001	3	view →
HNSC	Female	IV	+1.278	.010	2	view →
PRAD	All	All	−0.477	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CYYR1–KICH

Open the KICH breakdown →