CYTIP

Across TCGA patient cohorts, CYTIP mutation is significantly associated with the RNA expression of many other genes, with 1,698 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CYTIP-associated genes across cancer lineages are VPS18, ELOA, and GPN3. Each is linked with CYTIP in more than 3 cancer types. Because this analysis shows association rather than direction, both CYTIP-to-partner and partner-to-CYTIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VPS18 grouped by CYTIP-low versus CYTIP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYTIP→partner) and Y-score (partner→CYTIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	VPS18 →	+0.343	+2.385	.006	.002	3	3
SKCM	ELOA →	+0.385	+1.591	.001	.001	3	3
SKCM	GPN3 →	+0.368	+1.945	.007	.002	3	3
SKCM	DCLRE1B →	+0.339	+2.334	.007	.003	3	3
SKCM	CHCHD4 →	+0.246	+1.983	.009	.007	2	4
UCEC	CDT1 →	+0.974	+3.939	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,698 associations by consensus.

VPS18 by CYTIP expression — SKCM

Explore this box plot interactively →