CYTH1

Across TCGA patient cohorts, CYTH1 mutation is significantly associated with the RNA expression of many other genes, with 1,494 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYTH1-associated genes across cancer lineages are HIGD1AP10, DUTP5, and NOLC1P1. Each is linked with CYTH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYTH1-to-partner and partner-to-CYTH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIGD1AP10 grouped by CYTH1-low versus CYTH1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYTH1→partner) and Y-score (partner→CYTH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HIGD1AP10 →	+0.175	+3.630	<.001	.004	3	2
BLCA	DUTP5 →	+0.142	+5.899	<.001	.002	3	2
UCEC	NOLC1P1 →	+0.078	+1.622	<.001	.006	3	2
UCEC	EZH2P1 →	+0.316	+1.840	<.001	.002	3	2
UCEC	RN7SL654P →	+0.115	+2.846	<.001	<.001	3	2
UCEC	RN7SKP135 →	+0.039	+4.673	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,494 associations by consensus.

HIGD1AP10 by CYTH1 expression — SKCM

Explore this box plot interactively →