CYSLTR1

Across TCGA patient cohorts, CYSLTR1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYSLTR1-associated genes across cancer lineages are Cyclin-B1, 14-3-3_beta, and A-Raf_pS299. Each is linked with CYSLTR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYSLTR1-to-partner and partner-to-CYSLTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CYSLTR1-low versus CYSLTR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYSLTR1→partner) and Y-score (partner→CYSLTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.578	+2.999	.006	.035	3	2
UCEC	14-3-3_beta →	-0.114	-3.432	.002	.005	3	1
UCEC	A-Raf_pS299 →	-0.101	-1.807	.023	.025	3	1
UCEC	ACC_pS79 →	+0.299	+2.169	.021	.003	3	1
UCEC	ACC1 →	+0.277	+1.415	.042	.046	3	1
UCEC	MEK1 →	+0.484	+3.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Cyclin-B1 by CYSLTR1 expression — UCEC

Explore this box plot interactively →