CYSLTR1

Across TCGA pan-cancer cohorts, CYSLTR1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CYSLTR1 data layer compared with 5 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher CYSLTR1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CYSLTR1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, KIRC, and HNSC are the cancer types where CYSLTR1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.399	0.262	<.001	114	view →
KIRC	DFS	Median	All	0.709	0.552	<.001	110	view →
HNSC	DFS	Median	All	0.750	0.639	<.001	94	view →
CESC	OS	Median	All	0.871	0.722	<.001	84	view →
LUAD	DFS	Median	All	0.725	0.607	.001	42	view →
KIRP	DFS	Tertile	All	0.509	0.873	.001	35	view →
DLBC	DFS	Tertile	All	0.268	0.787	.007	27	view →
ACC	DFS	Tertile	All	0.890	0.405	<.001	26	view →
UCS	DFS	Tertile	IV	0.860	0.364	.024	18	view →
UVM	OS	Quartile	III,IV	0.503	0.914	.026	17	view →
CHOL	DFS	Median	All	0.666	0.135	.004	15	view →
KICH	DFS	Quartile	II,III,IV	0.459	1.000	.043	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CYSLTR1–SKCM (OS)

Open the SKCM breakdown →