CYSLTR1

Across TCGA cell cohorts, CYSLTR1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CYSLTR1-associated genes across cancer lineages are OR4D10, PROKR2, and BMX. Each is linked with CYSLTR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYSLTR1-to-partner and partner-to-CYSLTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4D10 grouped by CYSLTR1-low versus CYSLTR1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYSLTR1→partner) and Y-score (partner→CYSLTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR4D10 →	+0.022	+5.029	<.001	.006	3	1
BLOOD_Lymphoma	PROKR2 →	+0.039	+4.350	.006	.005	3	1
BLOOD_Lymphoma	BMX →	+0.497	+4.350	.006	.005	3	1
BLOOD_Lymphoma	BANF2 →	+0.071	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	DEFB129 →	+0.032	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	OR13C9 →	+0.024	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

OR4D10 by CYSLTR1 expression — LUNG_SCLC

Explore this box plot interactively →