Across TCGA cell cohorts, CYS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,302 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CYS1-associated GO terms across cancer lineages are Negative regulation of complement-dependent cytotoxicity, Protein targeting to lysosome involved in chaperone-mediated autophagy, and Negative regulation of activation of membrane attack complex. Each is linked with CYS1 in more than 9 cancer types. Because this analysis shows association rather than direction, both CYS1-to-partner and partner-to-CYS1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYS1→partner) and Y-score (partner→CYS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of complement-dependent cytotoxicity →	+0.236	+0.162	<.001	.004	3	10
BONE	Protein targeting to lysosome involved in chaperone-mediated autophagy →	+0.190	+1.355	<.001	.004	3	10
SOFT_TISSUE	Negative regulation of activation of membrane attack complex →	+0.144	+1.028	.002	.001	2	10
CNS	Cellular response to abiotic stimulus →	+0.027	+0.585	.008	.009	3	9
SOFT_TISSUE	Protein targeting to vacuole involved in autophagy →	+0.195	+1.168	<.001	.001	3	9
CNS	Cellular response to environmental stimulus →	+0.027	+0.585	.008	.009	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,302 associations by consensus.

Exploration

CYS1 survival (RNA) · tumor vs normal (RNA) · all CYS1 data types