CYRIB

Across TCGA pan-cancer cohorts, CYRIB mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CYRIB data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CYRIB mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CYRIB expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where CYRIB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	II,III,IV	1.000	0.437	.025	8	view →
LUAD	DFS	Quartile	II,III,IV	0.881	0.369	.016	6	view →
CCRCC	OS	Median	All	0.904	0.984	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CYRIB–UCEC (OS)

Open the UCEC breakdown →