CYRIB

Across TCGA pan-cancer cohorts, CYRIB RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CYRIB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CYRIB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CYRIB is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and KIRC are the cancer types where CYRIB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYRIB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.595	<.001	12	view →
BLCA	Male	III,IV	+1.601	<.001	11	view →
KIRC	Male	All	+0.460	<.001	10	view →
STAD	Female	All	+1.635	<.001	9	view →
LIHC	Male	II,III,IV	+1.380	<.001	9	view →
COAD	Male	II,III,IV	+0.671	<.001	9	view →
THCA	Male	III,IV	−0.639	<.001	8	view →
BRCA	All	II,III,IV	+0.951	<.001	6	view →
READ	Male	All	+0.933	.002	6	view →
UCEC	All	All	+0.603	.010	6	view →
KIRP	All	II,III,IV	+0.585	.003	6	view →
CHOL	All	All	+2.544	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CYRIB–HNSC

Open the HNSC breakdown →