CYRIB

Across TCGA patient cohorts, CYRIB protein abundance is significantly associated with the RNA expression of many other genes, with 17,804 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CYRIB-associated genes across cancer lineages are TLR8, TNFSF13B, and IL21R. Each is linked with CYRIB in more than 9 cancer types. Because this analysis shows association rather than direction, both CYRIB-to-partner and partner-to-CYRIB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYRIB versus TLR8 in OV, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYRIB→partner) and Y-score (partner→CYRIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TLR8 →	+0.968	+0.397	<.001	<.001	3	10
UCEC	TNFSF13B →	+1.129	+0.360	<.001	<.001	3	10
UCEC	IL21R →	+1.214	+0.414	<.001	<.001	3	10
UCEC	LILRB1 →	+1.215	+0.400	<.001	<.001	3	10
UCEC	IL10RA →	+1.288	+0.397	<.001	<.001	3	10
UCEC	BIN2 →	+1.223	+0.419	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,804 associations by consensus.

CYRIB vs TLR8 — OV

Explore this scatter interactively →