CYRIB

Across TCGA patient cohorts, CYRIB mutation is significantly associated with the RNA expression of many other genes, with 3,303 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYRIB-associated genes across cancer lineages are RNU6-1149P, MIR4445, and RN7SKP110. Each is linked with CYRIB in more than 1 cancer types. Because this analysis shows association rather than direction, both CYRIB-to-partner and partner-to-CYRIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1149P grouped by CYRIB-low versus CYRIB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYRIB→partner) and Y-score (partner→CYRIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1149P →	+0.176	+2.198	.005	.003	3	2
UCEC	MIR4445 →	+0.123	+3.893	<.001	.006	3	2
LUSC	RN7SKP110 →	+0.183	+3.748	.001	.008	3	2
LUSC	RNA5SP417 →	+0.547	+4.297	<.001	.009	3	2
LUSC	MRPS21P7 →	+0.347	+4.795	<.001	.001	3	2
BRCA	MIR8056 →	+0.448	+7.471	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,303 associations by consensus.

RNU6-1149P by CYRIB expression — UCEC

Explore this box plot interactively →