CYRIB

Across TCGA patient cohorts, CYRIB mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYRIB-associated genes across cancer lineages are ATM, EGFR_pY1068, and ER-alpha_pS118. Each is linked with CYRIB in more than 1 cancer types. Because this analysis shows association rather than direction, both CYRIB-to-partner and partner-to-CYRIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CYRIB-low versus CYRIB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYRIB→partner) and Y-score (partner→CYRIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.686	-3.571	<.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.244	-1.678	.011	.023	3	1
UCEC	ER-alpha_pS118 →	-0.409	-3.700	.002	.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.125	-2.797	.008	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.218	-3.906	<.001	<.001	3	1
UCEC	JNK2 →	+0.170	+1.678	.026	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ATM by CYRIB expression — UCEC

Explore this box plot interactively →