CYRIA

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CYRIA mutation is significantly associated with the RNA expression of many other genes, with 2,239 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYRIA-associated genes across cancer lineages are IKBKG, RNA5SP502, and MYO19. Each is linked with CYRIA in more than 1 cancer types. Because this analysis shows association rather than direction, both CYRIA-to-partner and partner-to-CYRIA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYRIA→partner) and Y-score (partner→CYRIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMIKBKG →+0.344+3.359.001.00432
LUSCRNA5SP502 →+0.221+4.724<.001.00532
UCECMYO19 →+0.516+2.736<.001<.00132
UCECDCTPP1 →+0.660+1.858<.001.00532
UCECSETD3 →+0.420+3.016<.001<.00132
UCECKMT5A →+0.399+3.048.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,239 associations by consensus.

Exploration