Across TCGA pan-cancer cohorts, CYRIA RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CYRIA’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CYRIA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CYRIA is over-expressed in tumor, although a few such as COAD and UCEC show the opposite, repressed pattern.
KIRC, COAD, and UCEC are the cancer types where CYRIA tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYRIA RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.