Across TCGA patient cohorts, CYRIA mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYRIA-associated genes across cancer lineages are JNK_pT183_Y185, DJ-1, and EGFR_pY1068. Each is linked with CYRIA in more than 1 cancer types. Because this analysis shows association rather than direction, both CYRIA-to-partner and partner-to-CYRIA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYRIA→partner) and Y-score (partner→CYRIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.142	-1.664	.028	.023	3	2
SKCM	DJ-1 →	+0.270	+3.807	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.226	-1.874	.019	.049	3	1
UCEC	A-Raf_pS299 →	-0.173	-2.087	<.001	.005	3	1
UCEC	IGFBP2 →	-0.660	-2.321	.008	.033	3	1
UCEC	ACVRL1 →	-0.105	-1.680	.045	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

CYRIA survival (RNA) · tumor vs normal (RNA) · all CYRIA data types