Across TCGA cell cohorts, CYRIA mutation is significantly associated with the mutation status of many other genes, with 3,473 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYRIA-associated genes across cancer lineages are ITGA8, PDE1C, and HIVEP2. Each is linked with CYRIA in more than 2 cancer types. Because this analysis shows association rather than direction, both CYRIA-to-partner and partner-to-CYRIA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYRIA→partner) and Y-score (partner→CYRIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGA8 →	+3.614	+4.278	<.001	<.001	1	3
BLOOD_Lymphoma	PDE1C →	+4.429	+5.247	.005	.005	1	3
LARGE_INTESTINE	HIVEP2 →	+2.155	+3.392	<.001	<.001	1	3
LARGE_INTESTINE	KNDC1 →	+1.932	+2.693	.004	.004	1	3
BLOOD_Lymphoma	ZSWIM8 →	+4.014	+4.969	.008	.008	1	2
BLOOD_Lymphoma	TLR9 →	+4.429	+5.247	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,473 associations by consensus.

Exploration

CYRIA survival (RNA) · tumor vs normal (RNA) · all CYRIA data types