Across TCGA cell cohorts, CYRIA mutation is significantly associated with the drug of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYRIA-associated genes across cancer lineages are SB505124, Belinostat, and CAY10603. Each is linked with CYRIA in more than 1 cancer types. Because this analysis shows association rather than direction, both CYRIA-to-partner and partner-to-CYRIA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYRIA→partner) and Y-score (partner→CYRIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SB505124 →	-0.482	-2.743	.029	.046	1	1
LARGE_INTESTINE	Belinostat →	-0.644	-2.595	.002	.049	1	1
LARGE_INTESTINE	CAY10603 →	-0.478	-2.740	.026	.045	1	1
LARGE_INTESTINE	NVP-BHG712 →	-0.594	-2.740	.010	.045	1	1
LARGE_INTESTINE	SB52334 →	-0.373	-2.740	.021	.045	1	1
LARGE_INTESTINE	SNX-2112 →	-0.951	-2.740	.003	.045	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

CYRIA survival (RNA) · tumor vs normal (RNA) · all CYRIA data types