CYP8B1

Across TCGA patient cohorts, CYP8B1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP8B1-associated genes across cancer lineages are ASNS, eIF4G, and Gab2. Each is linked with CYP8B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP8B1-to-partner and partner-to-CYP8B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CYP8B1-low versus CYP8B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP8B1→partner) and Y-score (partner→CYP8B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.532	+2.459	<.001	.018	3	3
UCEC	eIF4G →	+0.291	+2.321	.019	.033	3	2
UCEC	Gab2 →	+0.326	+2.999	.023	.035	3	2
UCEC	GAPDH →	+0.472	+3.169	.028	.018	3	2
UCEC	INPP4B →	-0.436	-3.700	<.001	.001	3	2
UCEC	p70-S6K →	+0.155	+1.894	.045	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ASNS by CYP8B1 expression — UCEC

Explore this box plot interactively →