CYP4Z2P

Across TCGA patient cohorts, CYP4Z2P mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP4Z2P-associated genes across cancer lineages are JNK_pT183_Y185, Caspase-8, and Snail. Each is linked with CYP4Z2P in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP4Z2P-to-partner and partner-to-CYP4Z2P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CYP4Z2P-low versus CYP4Z2P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4Z2P→partner) and Y-score (partner→CYP4Z2P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.139	-2.000	.040	.030	3	2
UCEC	Caspase-8 →	-0.251	-2.432	.013	.018	3	2
SKCM	Snail →	-0.156	-1.765	.014	.013	3	2
UCEC	EGFR_pY1068 →	-0.203	-2.000	.044	.030	3	1
UCEC	A-Raf_pS299 →	-0.121	-3.321	.011	.010	3	1
UCEC	Gab2 →	+0.414	+2.415	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

JNK_pT183_Y185 by CYP4Z2P expression — UCEC

Explore this box plot interactively →