CYP4Z2P

Across TCGA pan-cancer cohorts, CYP4Z2P RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated CYP4Z2P data layer compared with 2 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher CYP4Z2P RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CYP4Z2P expression acts as an unfavorable survival marker, although some lineages such as BLCA and CESC show a favorable association.

BLCA, UCEC, and KIRP are the cancer types where CYP4Z2P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	All	0.738	0.558	<.001	83	view →
UCEC	DFS	Quartile	All	0.561	0.772	<.001	72	view →
KIRP	DFS	Tertile	II,III,IV	0.483	0.750	.003	66	view →
CESC	OS	Tertile	IV	0.598	0.096	.008	30	view →
UCS	DFS	Median	II,III,IV	0.155	0.461	.032	24	view →
LUAD	OS	Quartile	All	0.462	0.211	<.001	24	view →
MESO	OS	Tertile	All	0.843	0.184	.001	23	view →
READ	OS	Tertile	III,IV	0.214	0.796	.001	21	view →
CHOL	DFS	Quartile	All	0.795	0.267	.007	15	view →
OV	OS	Quartile	IV	0.278	0.584	.012	12	view →
STAD	OS	Median	IV	0.561	0.158	.016	12	view →
COAD	DFS	Tertile	II,III,IV	0.418	0.665	.036	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

CYP4Z2P–BLCA (DFS)

Open the BLCA breakdown →