CYP4V2

Across TCGA patient cohorts, CYP4V2 mutation is significantly associated with the RNA expression of many other genes, with 1,457 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP4V2-associated genes across cancer lineages are GPX4, AGPAT5P1, and FAM204DP. Each is linked with CYP4V2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP4V2-to-partner and partner-to-CYP4V2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPX4 grouped by CYP4V2-low versus CYP4V2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4V2→partner) and Y-score (partner→CYP4V2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GPX4 →	+0.412	+2.301	.007	.001	3	2
COAD	AGPAT5P1 →	+0.061	+4.721	<.001	.004	3	2
LUSC	FAM204DP →	+0.153	+4.781	<.001	.003	3	2
COAD	PRPF19P1 →	+0.092	+3.408	.001	.009	3	2
BLCA	RNU6-1183P →	+0.983	+5.497	<.001	.004	3	2
LUAD	RN7SKP189 →	+1.088	+5.197	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,457 associations by consensus.

GPX4 by CYP4V2 expression — UCEC

Explore this box plot interactively →