Across TCGA patient cohorts, CYP4F8 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP4F8-associated genes across cancer lineages are PKC-b-II_pS660, Chk1, and c-Met_pY1235. Each is linked with CYP4F8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP4F8-to-partner and partner-to-CYP4F8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4F8→partner) and Y-score (partner→CYP4F8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PKC-b-II_pS660 →	-0.816	-3.000	<.001	.035	3	3
LUAD	Chk1 →	+0.427	+3.000	<.001	.036	3	3
LUAD	c-Met_pY1235 →	+0.156	+3.012	.004	.018	3	3
UCEC	PKC-delta_pS664 →	-0.142	-2.700	.001	.005	3	3
UCEC	4E-BP1 →	+0.391	+2.700	<.001	.005	3	3
LUAD	Mre11 →	+0.191	+3.000	.004	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Exploration

CYP4F8 survival (RNA) · tumor vs normal (RNA) · all CYP4F8 data types