Across TCGA pan-cancer cohorts, CYP4F8 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CYP4F8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CYP4F8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CYP4F8 is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.

COAD, PRAD, and STAD are the cancer types where CYP4F8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP4F8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	+0.124	<.001	7	view →
PRAD	All	All	−1.358	.004	2	view →
STAD	All	II,III,IV	+0.069	.011	2	view →
LUSC	All	All	+0.044	.012	2	view →
LUAD	All	All	+0.006	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: CYP4F8 RNA expression & survival · all CYP4F8 data types