CYP4F27P

Across TCGA pan-cancer cohorts, CYP4F27P RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated CYP4F27P data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher CYP4F27P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CYP4F27P expression acts as an unfavorable survival marker, although some lineages such as PAAD and UCEC show a favorable association.

UVM, THCA, and DLBC are the cancer types where CYP4F27P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.136	0.919	<.001	90	view →
THCA	OS	Tertile	All	0.229	0.948	<.001	90	view →
DLBC	DFS	Tertile	II,III,IV	0.065	0.829	<.001	72	view →
LIHC	DFS	Tertile	All	0.261	0.573	<.001	72	view →
KIRP	DFS	Tertile	All	0.673	0.918	.001	60	view →
COAD	DFS	Tertile	All	0.418	0.710	<.001	39	view →
PAAD	DFS	Tertile	All	0.715	0.251	.006	36	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	36	view →
UCEC	OS	Quartile	III,IV	0.932	0.796	.011	28	view →
LUSC	DFS	Quartile	III,IV	0.330	0.604	.005	26	view →
LGG	OS	Tertile	All	0.607	0.911	.001	24	view →
TGCT	DFS	Tertile	II,III,IV	0.621	0.949	.034	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

CYP4F27P–UVM (OS)

Open the UVM breakdown →