CYP4B1

Across TCGA patient cohorts, CYP4B1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP4B1-associated genes across cancer lineages are FoxM1, GATA6, and PRAS40_pT246. Each is linked with CYP4B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP4B1-to-partner and partner-to-CYP4B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by CYP4B1-low versus CYP4B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4B1→partner) and Y-score (partner→CYP4B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.277	+3.331	.009	.005	3	2
UCEC	GATA6 →	-0.181	-1.800	.004	.027	3	2
UCEC	PRAS40_pT246 →	+0.187	+2.115	.008	.017	3	2
UCEC	Beclin →	-0.080	-2.321	.040	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.693	+3.321	.004	.009	3	2
UCEC	Cyclin-B1 →	+0.742	+3.321	.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

FoxM1 by CYP4B1 expression — UCEC

Explore this box plot interactively →