CYP4B1

Across TCGA cell cohorts, CYP4B1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,056 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CYP4B1-associated GO terms across cancer lineages are Response to indole-3-methanol, Regulation of endoplasmic reticulum unfolded protein response, and Negative regulation of endoplasmic reticulum unfolded protein response. Each is linked with CYP4B1 in more than 7 cancer types. Because this analysis shows association rather than direction, both CYP4B1-to-partner and partner-to-CYP4B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to indole-3-methanol grouped by CYP4B1-low versus CYP4B1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4B1→partner) and Y-score (partner→CYP4B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Response to indole-3-methanol →	+0.247	+1.686	<.001	.004	3	8
BREAST	Regulation of endoplasmic reticulum unfolded protein response →	+0.085	+2.419	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Negative regulation of endoplasmic reticulum unfolded protein response →	+0.064	+1.251	.003	.004	3	7
LUNG_NSCLC_LUAD	Negative regulation of mast cell degranulation →	+0.935	+0.760	<.001	.004	3	7
LUNG_NSCLC_LUAD	Establishment of epithelial cell apical/basal polarity →	-0.190	-0.986	<.001	<.001	3	7
LUNG_NSCLC_LUAD	Bundle of His cell to Purkinje myocyte communication →	+0.217	+0.725	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,056 associations by consensus.

Response to indole-3-methanol by CYP4B1 expression — URINARY_TRACT

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