CYP46A4P

Across TCGA pan-cancer cohorts, CYP46A4P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CYP46A4P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CYP46A4P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CYP46A4P is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

HNSC, BRCA, and KIRC are the cancer types where CYP46A4P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP46A4P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.069	.027	6	view →
BRCA	Female	All	−0.061	.003	4	view →
KIRC	All	All	+0.042	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

CYP46A4P–HNSC

Open the HNSC breakdown →