CYP3A5

Across TCGA cell cohorts, CYP3A5 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP3A5-associated genes across cancer lineages are DAZ3, OR51A4, and SMIM28. Each is linked with CYP3A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP3A5-to-partner and partner-to-CYP3A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAZ3 grouped by CYP3A5-low versus CYP3A5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP3A5→partner) and Y-score (partner→CYP3A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DAZ3 →	+0.754	+4.115	<.001	.001	3	1
SKIN	OR51A4 →	+0.006	+4.022	<.001	.006	3	1
SKIN	SMIM28 →	+0.013	+4.022	<.001	.006	3	1
BREAST	OR1L3 →	+0.022	+5.169	<.001	.005	3	1
BREAST	OR4E1 →	+0.150	+5.781	<.001	.001	3	1
LARGE_INTESTINE	KLF1 →	+0.086	+3.215	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

DAZ3 by CYP3A5 expression — SKIN

Explore this box plot interactively →