CYP3A4

Across TCGA cell cohorts, CYP3A4 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP3A4-associated genes across cancer lineages are SSMEM1, S100G, and TFDP3. Each is linked with CYP3A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP3A4-to-partner and partner-to-CYP3A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSMEM1 grouped by CYP3A4-low versus CYP3A4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP3A4→partner) and Y-score (partner→CYP3A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SSMEM1 →	+0.026	+4.252	<.001	<.001	3	1
LARGE_INTESTINE	S100G →	+1.023	+2.688	<.001	.008	3	1
LARGE_INTESTINE	TFDP3 →	+0.025	+3.781	<.001	<.001	3	1
LARGE_INTESTINE	CYP4Z1 →	+0.236	+3.531	.001	.007	3	1
LARGE_INTESTINE	OR2J3 →	+0.028	+2.657	.001	.007	3	1
LARGE_INTESTINE	LINGO4 →	+0.120	+3.869	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

SSMEM1 by CYP3A4 expression — LARGE_INTESTINE

Explore this box plot interactively →