CYP2W1

Across TCGA cell cohorts, CYP2W1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP2W1-associated genes across cancer lineages are SCN10A, TPD52L3, and FCGR3A. Each is linked with CYP2W1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2W1-to-partner and partner-to-CYP2W1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCN10A grouped by CYP2W1-low versus CYP2W1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2W1→partner) and Y-score (partner→CYP2W1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SCN10A →	+0.006	+5.196	<.001	.005	3	1
LUNG_NSCLC_LUAD	TPD52L3 →	+0.316	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	FCGR3A →	+0.042	+3.951	.003	.005	3	1
LARGE_INTESTINE	HTR1E →	+0.070	+3.345	<.001	.007	3	1
LARGE_INTESTINE	ZBBX →	+0.103	+3.658	.002	.005	3	1
LARGE_INTESTINE	S100G →	+1.376	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

SCN10A by CYP2W1 expression — OVARY

Explore this box plot interactively →