CYP2U1

Across TCGA cell cohorts, CYP2U1 mutation is significantly associated with the drug of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP2U1-associated genes across cancer lineages are PRT062607, Nelarabine, and CZC24832. Each is linked with CYP2U1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2U1-to-partner and partner-to-CYP2U1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRT062607 grouped by CYP2U1-low versus CYP2U1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2U1→partner) and Y-score (partner→CYP2U1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRT062607 →	+0.506	+2.769	.046	.040	3	1
LARGE_INTESTINE	Nelarabine →	+0.291	+2.649	.027	.046	3	1
LARGE_INTESTINE	CZC24832 →	+0.265	+2.646	.042	.047	2	1
LARGE_INTESTINE	PAK_5339 →	+0.383	+2.678	.009	.037	2	1
LARGE_INTESTINE	Zoledronate →	+0.293	+2.649	.037	.046	2	1
LARGE_INTESTINE	Quizartinib →	+0.462	+2.652	.003	.045	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PRT062607 by CYP2U1 expression — LARGE_INTESTINE

Explore this box plot interactively →