CYP2U1-AS1

Across TCGA pan-cancer cohorts, CYP2U1-AS1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CYP2U1-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher CYP2U1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CYP2U1-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and LIHC show a favorable association.

UVM, HNSC, and LIHC are the cancer types where CYP2U1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.828	0.461	<.001	88	view →
HNSC	OS	Tertile	III,IV	0.320	0.452	.007	66	view →
LIHC	OS	Median	III,IV	0.484	0.216	<.001	57	view →
ESCA	OS	Quartile	II,III,IV	0.253	0.611	.003	30	view →
UCEC	DFS	Tertile	All	0.876	0.918	.015	24	view →
LAML	DFS	Tertile	All	0.240	0.645	.001	22	view →
THYM	OS	Median	All	0.967	0.732	.003	20	view →
LUSC	OS	Quartile	III,IV	0.230	0.744	.015	20	view →
SKCM	DFS	Tertile	All	0.684	0.554	.007	17	view →
DLBC	DFS	Median	II,III,IV	1.000	0.647	.002	17	view →
MESO	DFS	Quartile	II,III,IV	0.526	0.310	.034	15	view →
KIRC	DFS	Quartile	II,III,IV	0.429	0.629	.016	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CYP2U1-AS1–UVM (OS)

Open the UVM breakdown →