CYP2U1-AS1

Across TCGA pan-cancer cohorts, CYP2U1-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CYP2U1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CYP2U1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types CYP2U1-AS1 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, LUSC, and BRCA are the cancer types where CYP2U1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP2U1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−0.106	<.001	10	view →
LUSC	Male	II,III,IV	−0.373	<.001	8	view →
BRCA	All	III,IV	−0.278	<.001	8	view →
LIHC	Female	II,III,IV	−0.179	<.001	4	view →
HNSC	All	IV	−0.081	.016	4	view →
KIRC	All	All	−0.026	.013	4	view →
THCA	Female	All	−0.175	.002	3	view →
KICH	All	All	−0.085	.019	3	view →
CHOL	All	All	−0.151	<.001	2	view →
READ	All	All	−0.150	.003	2	view →
LUAD	Female	II,III,IV	−0.164	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CYP2U1-AS1–COAD

Open the COAD breakdown →