CYP2T1P

Across TCGA pan-cancer cohorts, CYP2T1P RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CYP2T1P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CYP2T1P RNA is repressed in tumor relative to normal tissue. In most cancer types CYP2T1P is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KICH, HNSC, and KIRC are the cancer types where CYP2T1P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP2T1P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−1.967	<.001	10	view →
HNSC	All	II,III,IV	−0.648	<.001	10	view →
KIRC	Male	II,III,IV	−0.883	<.001	9	view →
UCEC	All	All	−1.549	<.001	6	view →
BRCA	All	III,IV	+1.261	.016	6	view →
KIRP	All	All	−0.814	<.001	5	view →
READ	Male	All	−0.783	.006	5	view →
CHOL	All	All	+1.506	<.001	4	view →
LIHC	All	All	+0.381	.012	4	view →
PRAD	All	All	−1.116	<.001	2	view →
THCA	Male	All	−0.412	.023	2	view →
LUSC	All	All	−0.370	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CYP2T1P–KICH

Open the KICH breakdown →