CYP2S1

Across TCGA cell cohorts, CYP2S1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP2S1-associated genes across cancer lineages are PRDM7, PRMT9, and CPLX4. Each is linked with CYP2S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2S1-to-partner and partner-to-CYP2S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDM7 grouped by CYP2S1-low versus CYP2S1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2S1→partner) and Y-score (partner→CYP2S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRDM7 →	+0.177	+3.761	<.001	.001	3	1
LARGE_INTESTINE	PRMT9 →	+0.740	+3.192	<.001	.007	3	1
LARGE_INTESTINE	CPLX4 →	+0.020	+2.444	.002	.008	3	1
LARGE_INTESTINE	GFRA2 →	+0.039	+2.839	<.001	.004	3	1
LARGE_INTESTINE	DCAF12L1 →	+0.006	+2.672	.007	.004	3	1
LARGE_INTESTINE	COL11A2 →	+0.575	+3.131	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

PRDM7 by CYP2S1 expression — LARGE_INTESTINE

Explore this box plot interactively →