CYP2J2

Across TCGA patient cohorts, CYP2J2 mutation is significantly associated with the RNA expression of many other genes, with 579 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2J2-associated genes across cancer lineages are ONECUT2, NECTIN4, and MIR8062. Each is linked with CYP2J2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2J2-to-partner and partner-to-CYP2J2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ONECUT2 grouped by CYP2J2-low versus CYP2J2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2J2→partner) and Y-score (partner→CYP2J2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ONECUT2 →	+0.465	+2.794	.007	.002	3	2
UCEC	NECTIN4 →	-0.796	-2.076	.004	.006	3	2
SKCM	MIR8062 →	+0.112	+3.723	<.001	.009	3	2
UCEC	IGLV2-8 →	+1.748	+2.711	<.001	.003	3	1
UCEC	MIR6803 →	+0.186	+4.893	<.001	<.001	3	1
UCEC	MIR6865 →	+0.540	+1.774	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 579 associations by consensus.

ONECUT2 by CYP2J2 expression — UCEC

Explore this box plot interactively →