Across TCGA patient cohorts, CYP2D7 mutation is significantly associated with the RNA expression of many other genes, with 1,490 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2D7-associated genes across cancer lineages are TUBB1P2, TRAJ57, and TRAJ38. Each is linked with CYP2D7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2D7-to-partner and partner-to-CYP2D7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2D7→partner) and Y-score (partner→CYP2D7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TUBB1P2 →	+0.034	+7.741	<.001	.009	3	2
UCEC	TRAJ57 →	+0.543	+2.582	<.001	.001	3	2
UCEC	TRAJ38 →	+0.428	+2.311	<.001	.004	3	2
UCEC	MAGI2-AS2 →	+0.104	+3.220	<.001	.005	3	2
UCEC	RNU6-964P →	+0.432	+2.051	.001	.006	3	2
BRCA	MIR6825 →	+0.335	+4.920	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,490 associations by consensus.

Exploration

CYP2D7 survival (RNA) · tumor vs normal (RNA) · all CYP2D7 data types