Across TCGA pan-cancer cohorts, CYP2D7 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CYP2D7’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where CYP2D7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CYP2D7 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.
COAD, HNSC, and KIRC are the cancer types where CYP2D7 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP2D7 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.