Across TCGA patient cohorts, CYP2D7 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2D7-associated genes across cancer lineages are Class-switched memory B-cells, aDC, and Plasma cells. Each is linked with CYP2D7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2D7-to-partner and partner-to-CYP2D7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2D7→partner) and Y-score (partner→CYP2D7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Class-switched memory B-cells →	-0.060	-2.807	.016	.003	2	1
UCEC	aDC →	+0.085	+1.595	.008	.045	1	1
UCEC	Plasma cells →	-0.022	-2.072	.018	.019	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

CYP2D7 survival (RNA) · tumor vs normal (RNA) · all CYP2D7 data types