Across TCGA cell cohorts, CYP2D7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,204 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP2D7-associated GO terms across cancer lineages are Cilium or flagellum-dependent cell motility, Cilium-dependent cell motility, and Flagellated sperm motility. Each is linked with CYP2D7 in more than 14 cancer types. Because this analysis shows association rather than direction, both CYP2D7-to-partner and partner-to-CYP2D7 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2D7→partner) and Y-score (partner→CYP2D7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.098	-0.884	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.098	-0.884	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.140	-1.242	<.001	<.001	3	14
BONE	Late viral transcription →	+0.136	+0.900	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.101	-0.884	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.132	+0.896	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,204 associations by consensus.

Exploration

CYP2D7 survival (RNA) · tumor vs normal (RNA) · all CYP2D7 data types