CYP2C9

Across TCGA patient cohorts, CYP2C9 mutation is significantly associated with the RNA expression of many other genes, with 2,721 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2C9-associated genes across cancer lineages are RCC1, RNU6-788P, and RNU6-296P. Each is linked with CYP2C9 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP2C9-to-partner and partner-to-CYP2C9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCC1 grouped by CYP2C9-low versus CYP2C9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C9→partner) and Y-score (partner→CYP2C9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RCC1 →	+0.417	+2.748	.006	.003	3	3
UCEC	RNU6-788P →	+0.132	+3.002	<.001	.006	3	3
SARC	RNU6-296P →	+0.738	+5.620	<.001	.004	3	3
UCEC	COX15 →	+0.414	+2.874	.001	<.001	3	3
UCEC	NAE1 →	+0.449	+1.955	.004	.008	3	3
UCEC	DOLPP1 →	+0.619	+2.885	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,721 associations by consensus.

RCC1 by CYP2C9 expression — UCEC

Explore this box plot interactively →