CYP2C9

Across TCGA cell cohorts, CYP2C9 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP2C9-associated genes across cancer lineages are OR10W1, SLC6A19, and C14orf180. Each is linked with CYP2C9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2C9-to-partner and partner-to-CYP2C9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by CYP2C9-low versus CYP2C9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C9→partner) and Y-score (partner→CYP2C9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.010	+2.977	<.001	.006	3	1
LARGE_INTESTINE	SLC6A19 →	+1.215	+3.302	<.001	.008	3	1
LARGE_INTESTINE	C14orf180 →	+0.123	+3.155	<.001	<.001	3	1
LARGE_INTESTINE	OR13C7 →	+0.012	+3.415	<.001	.001	3	1
LUNG_NSCLC_LUAD	MYF5 →	+0.995	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	CTXN3 →	+0.028	+4.212	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

OR10W1 by CYP2C9 expression — LARGE_INTESTINE

Explore this box plot interactively →