CYP2A6

Across TCGA patient cohorts, CYP2A6 mutation is significantly associated with the RNA expression of many other genes, with 1,165 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2A6-associated genes across cancer lineages are RPL23AP82, CIDECP1, and FOCAD-AS1. Each is linked with CYP2A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2A6-to-partner and partner-to-CYP2A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP82 grouped by CYP2A6-low versus CYP2A6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2A6→partner) and Y-score (partner→CYP2A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL23AP82 →	+0.384	+3.708	<.001	<.001	3	2
UCEC	CIDECP1 →	+0.357	+2.892	<.001	.001	3	2
UCEC	FOCAD-AS1 →	+0.282	+3.719	.007	<.001	3	2
UCEC	USP9YP2 →	+0.012	+4.481	<.001	.002	3	2
SKCM	SEPTIN7P5 →	+0.035	+2.877	<.001	.009	3	2
SKCM	LBX2 →	+0.793	+3.469	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,165 associations by consensus.

RPL23AP82 by CYP2A6 expression — UCEC

Explore this box plot interactively →