CYP26B1

Across TCGA cell cohorts, CYP26B1 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CYP26B1-associated genes across cancer lineages are C9, MNDA, and OR6C70. Each is linked with CYP26B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP26B1-to-partner and partner-to-CYP26B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9 grouped by CYP26B1-low versus CYP26B1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP26B1→partner) and Y-score (partner→CYP26B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C9 →	+0.214	+3.763	<.001	.002	3	1
LUNG_NSCLC_LUAD	MNDA →	+0.100	+3.466	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR6C70 →	+0.208	+3.944	<.001	.006	3	1
LUNG_NSCLC_LUAD	TEX33 →	+0.015	+3.944	<.001	.006	3	1
LUNG_NSCLC_LUAD	PRSS38 →	+0.028	+3.415	.009	.002	3	1
LUNG_NSCLC_LUAD	LILRA5 →	+0.019	+3.189	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

C9 by CYP26B1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →